Biology of the most beautiful trio – Biology – pharmaceutical industries – Angle Seat Valve Manufacturer

80 years of the 20th century, for the same interest, three American scientists to each other Cooperation To solve the field of cell biology an important issue, it was discovered that this issue Cancer Closely related to the occurrence and aging; 20 years, their cooperation and scientific research received the highest reward.

2009 10 5, Sweden's Karolinska Institute announced the 2009 Nobel Prize in Physiology or Medicine University of California, San Francisco campus of Elizabeth? Blackburn, John Hopkins School of Medicine of the card Luo Er? Greider, and Harvard Medical School and Massachusetts General Hospital, Jack? Shostak, in recognition of their "discovery of telomere and telomerase to protect the chromosomes," they would mean this year's Nobel Prize in Physiology or share Medicine award bonuses.

Cooperation and support between three and discovered a secret life in progress, and scientific research in the process to deduce the most beautiful song trio, including a family history, teacher outstanding students, cooperation and sharing moving movement. In the presentation the day of interview, Blackburn said: "The basic research was so celebrated, and I therefore shiver."

Telomere of the past and In fact, interest in human telomeres can be traced back to the 20th century 30's and 40's.

Time, biologist Barbara? McClintock and Holman? Mahler were in maize and Drosophila genome found a similar problem: broken ends of chromosomes and the chromosomes from the middle stump different not as frequent as the stump end of the rearrangement. In 1938, Mahler will be the special structure of this chromosome ends called "telomeres" They have won the Nobel Prize in Physiology or Medicine, but they were not advanced tools and means to further study the molecular level of telomere the structure and function, then there is no access to the field researchers to follow, because the specific DNA is difficult to isolate and study.

Now, because of women scientists for outstanding performance, telomere research has become a well-known in the field, Greider attributed to the "founder effect", the founder is a Yale University molecular biologist Joseph? High Er.

20 century, mid 70s, Blackburn received his PhD at Cambridge University, she hoped that the new sequencing methods to the study of telomeres. She went to Yale University to do postdoctoral laboratory Gore, the two decided to study a unique single-celled organisms?? Tetrahymena. In its life cycle, Tetrahymena broken into the chromosome will be 10 000 short films, each one has a telomere. In 1978, they found that caps the end of chromosomes is six base pairs tandem repeat sequences and the formation of 20 to 70.

For Shostak, in the period 1974 to 1979, he was at Cornell University molecular biologists and geneticists to follow the ethnic Chinese Wu-side to do Ph.D., and stay in Wu Rui's laboratory postdoctoral, and then he went to Harvard College of Medicine assistant professor of Cancer Research, established his own laboratory. In 1980, he was at a meeting heard the report of Blackburn decided to work with her to see whether yeast telomeres also play a role.

Help in Blackburn, Shostak identified in yeast telomere, they proposed a conjecture, therefore, the cell is bound to have a specific enzyme to the telomere repeat fragment added chromosome end of DNA replication enzymes to compensate for incomplete work. In 1982, their research papers published in the "cell" magazine.

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